Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1303157..1303686 Replicon chromosome
Accession NZ_CP126631
Organism Staphylococcus aureus strain 33-40

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QPR37_RS06285 Protein ID WP_063652353.1
Coordinates 1303324..1303686 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QPR37_RS06280 Protein ID WP_000948331.1
Coordinates 1303157..1303327 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR37_RS06250 (QPR37_06250) 1298193..1298753 + 561 WP_063652345.1 K(+)-transporting ATPase subunit C -
QPR37_RS06255 (QPR37_06255) 1298962..1299441 + 480 WP_001287074.1 hypothetical protein -
QPR37_RS06260 (QPR37_06260) 1299434..1301017 + 1584 WP_063652347.1 PH domain-containing protein -
QPR37_RS06265 (QPR37_06265) 1301004..1301495 + 492 WP_078316666.1 PH domain-containing protein -
QPR37_RS06270 (QPR37_06270) 1301499..1301858 + 360 WP_000581197.1 holo-ACP synthase -
QPR37_RS06275 (QPR37_06275) 1301924..1303072 + 1149 WP_063652351.1 alanine racemase -
QPR37_RS06280 (QPR37_06280) 1303157..1303327 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QPR37_RS06285 (QPR37_06285) 1303324..1303686 + 363 WP_063652353.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QPR37_RS06290 (QPR37_06290) 1304035..1305036 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QPR37_RS06295 (QPR37_06295) 1305155..1305481 + 327 WP_285159264.1 anti-sigma factor antagonist -
QPR37_RS06300 (QPR37_06300) 1305483..1305962 + 480 WP_001190825.1 anti-sigma B factor RsbW -
QPR37_RS06305 (QPR37_06305) 1305937..1306707 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T282995 WP_063652353.1 NZ_CP126631:1303324-1303686 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNVVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282995 WP_000948331.1 NZ_CP126631:1303157-1303327 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References