Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1283429..1283943 Replicon chromosome
Accession NZ_CP126631
Organism Staphylococcus aureus strain 33-40

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QPR37_RS06195 Protein ID WP_000581792.1
Coordinates 1283734..1283943 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag QPR37_RS06190 Protein ID WP_000138934.1
Coordinates 1283429..1283722 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR37_RS06170 (QPR37_06170) 1278750..1279391 + 642 WP_063652329.1 thiamine phosphate synthase -
QPR37_RS06175 (QPR37_06175) 1279477..1280349 + 873 WP_000725802.1 membrane protein insertase YidC -
QPR37_RS06180 (QPR37_06180) 1281104..1281751 - 648 WP_063652331.1 HD domain-containing protein -
QPR37_RS06185 (QPR37_06185) 1281779..1283263 - 1485 WP_000571549.1 cardiolipin synthase -
QPR37_RS06190 (QPR37_06190) 1283429..1283722 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
QPR37_RS06195 (QPR37_06195) 1283734..1283943 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QPR37_RS06200 (QPR37_06200) 1284071..1284208 + 138 WP_000828354.1 Lmo0850 family protein -
QPR37_RS06205 (QPR37_06205) 1284475..1285677 - 1203 WP_259378900.1 FtsW/RodA/SpoVE family cell cycle protein -
QPR37_RS06210 (QPR37_06210) 1285995..1287065 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QPR37_RS06215 (QPR37_06215) 1287080..1288438 + 1359 WP_063652333.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T282994 WP_000581792.1 NZ_CP126631:1283734-1283943 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT282994 WP_000138934.1 NZ_CP126631:1283429-1283722 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References