Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2584044..2584573 Replicon chromosome
Accession NZ_CP126629
Organism Staphylococcus aureus strain 35-42

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QPL68_RS12540 Protein ID WP_063652353.1
Coordinates 2584211..2584573 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QPL68_RS12535 Protein ID WP_000948331.1
Coordinates 2584044..2584214 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL68_RS12505 (QPL68_12505) 2579080..2579640 + 561 WP_063652345.1 K(+)-transporting ATPase subunit C -
QPL68_RS12510 (QPL68_12510) 2579849..2580328 + 480 WP_001287074.1 hypothetical protein -
QPL68_RS12515 (QPL68_12515) 2580321..2581904 + 1584 WP_063652347.1 PH domain-containing protein -
QPL68_RS12520 (QPL68_12520) 2581891..2582382 + 492 WP_078316666.1 PH domain-containing protein -
QPL68_RS12525 (QPL68_12525) 2582386..2582745 + 360 WP_000581197.1 holo-ACP synthase -
QPL68_RS12530 (QPL68_12530) 2582811..2583959 + 1149 WP_063652351.1 alanine racemase -
QPL68_RS12535 (QPL68_12535) 2584044..2584214 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QPL68_RS12540 (QPL68_12540) 2584211..2584573 + 363 WP_063652353.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QPL68_RS12545 (QPL68_12545) 2584922..2585923 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QPL68_RS12550 (QPL68_12550) 2586042..2586368 + 327 WP_001052796.1 anti-sigma factor antagonist -
QPL68_RS12555 (QPL68_12555) 2586370..2586849 + 480 WP_001190825.1 anti-sigma B factor RsbW -
QPL68_RS12560 (QPL68_12560) 2586824..2587594 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T282987 WP_063652353.1 NZ_CP126629:2584211-2584573 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNVVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282987 WP_000948331.1 NZ_CP126629:2584044-2584214 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References