Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2564316..2564830 Replicon chromosome
Accession NZ_CP126629
Organism Staphylococcus aureus strain 35-42

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QPL68_RS12450 Protein ID WP_000581792.1
Coordinates 2564621..2564830 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag QPL68_RS12445 Protein ID WP_000138934.1
Coordinates 2564316..2564609 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL68_RS12425 (QPL68_12425) 2559637..2560278 + 642 WP_063652329.1 thiamine phosphate synthase -
QPL68_RS12430 (QPL68_12430) 2560364..2561236 + 873 WP_000725802.1 membrane protein insertase YidC -
QPL68_RS12435 (QPL68_12435) 2561991..2562638 - 648 WP_063652331.1 HD domain-containing protein -
QPL68_RS12440 (QPL68_12440) 2562666..2564150 - 1485 WP_000571549.1 cardiolipin synthase -
QPL68_RS12445 (QPL68_12445) 2564316..2564609 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
QPL68_RS12450 (QPL68_12450) 2564621..2564830 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QPL68_RS12455 (QPL68_12455) 2564958..2565095 + 138 WP_000828354.1 Lmo0850 family protein -
QPL68_RS12460 (QPL68_12460) 2565362..2566564 - 1203 WP_259378900.1 FtsW/RodA/SpoVE family cell cycle protein -
QPL68_RS12465 (QPL68_12465) 2566882..2567952 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QPL68_RS12470 (QPL68_12470) 2567967..2569325 + 1359 WP_063652333.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T282986 WP_000581792.1 NZ_CP126629:2564621-2564830 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT282986 WP_000138934.1 NZ_CP126629:2564316-2564609 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References