Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 54990..55766 Replicon chromosome
Accession NZ_CP126629
Organism Staphylococcus aureus strain 35-42

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QPL68_RS00410 Protein ID WP_000031108.1
Coordinates 55614..55766 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag QPL68_RS00405 Protein ID WP_063652486.1
Coordinates 54990..55589 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL68_RS00385 (QPL68_00385) 50905..52362 + 1458 WP_259378840.1 ABC transporter permease subunit -
QPL68_RS00390 (QPL68_00390) 52355..53077 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QPL68_RS00395 (QPL68_00395) 53228..54355 + 1128 WP_063652481.1 tRNA epoxyqueuosine(34) reductase QueG -
QPL68_RS00400 (QPL68_00400) 54360..54866 + 507 WP_063652483.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QPL68_RS00405 (QPL68_00405) 54990..55589 + 600 WP_063652486.1 hypothetical protein Antitoxin
QPL68_RS00410 (QPL68_00410) 55614..55766 + 153 WP_000031108.1 SAS053 family protein Toxin
QPL68_RS00415 (QPL68_00415) 56426..56821 + 396 WP_063652488.1 hypothetical protein -
QPL68_RS00420 (QPL68_00420) 57017..58402 + 1386 WP_063652489.1 class II fumarate hydratase -
QPL68_RS00425 (QPL68_00425) 58851..59672 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282979 WP_000031108.1 NZ_CP126629:55614-55766 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.54 Da        Isoelectric Point: 5.3978

>AT282979 WP_063652486.1 NZ_CP126629:54990-55589 [Staphylococcus aureus]
MAMNFKVFDNSKLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References