Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2119783..2120297 Replicon chromosome
Accession NZ_CP126627
Organism Staphylococcus aureus strain 17-21

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag QPR40_RS10470 Protein ID WP_000581794.1
Coordinates 2119783..2119992 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QPR40_RS10475 Protein ID WP_000138932.1
Coordinates 2120004..2120297 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR40_RS10450 (QPR40_10450) 2115291..2116649 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QPR40_RS10455 (QPR40_10455) 2116664..2117734 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
QPR40_RS10460 (QPR40_10460) 2118052..2119254 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QPR40_RS10465 (QPR40_10465) 2119518..2119655 - 138 WP_000828354.1 Lmo0850 family protein -
QPR40_RS10470 (QPR40_10470) 2119783..2119992 - 210 WP_000581794.1 heavy metal-associated domain-containing protein Toxin
QPR40_RS10475 (QPR40_10475) 2120004..2120297 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QPR40_RS10480 (QPR40_10480) 2120463..2121947 + 1485 WP_000571549.1 cardiolipin synthase -
QPR40_RS10485 (QPR40_10485) 2121975..2122622 + 648 WP_001187630.1 HD domain-containing protein -
QPR40_RS10490 (QPR40_10490) 2123227..2124099 - 873 WP_000725802.1 membrane protein insertase YidC -
QPR40_RS10495 (QPR40_10495) 2124185..2124826 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7833.73 Da        Isoelectric Point: 4.1008

>T282973 WP_000581794.1 NZ_CP126627:c2119992-2119783 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETSANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT282973 WP_000138932.1 NZ_CP126627:c2120297-2120004 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References