Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2100029..2100558 Replicon chromosome
Accession NZ_CP126627
Organism Staphylococcus aureus strain 17-21

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QPR40_RS10380 Protein ID WP_000621175.1
Coordinates 2100029..2100391 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QPR40_RS10385 Protein ID WP_000948331.1
Coordinates 2100388..2100558 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR40_RS10360 (QPR40_10360) 2097007..2097777 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
QPR40_RS10365 (QPR40_10365) 2097752..2098231 - 480 WP_001190829.1 anti-sigma B factor RsbW -
QPR40_RS10370 (QPR40_10370) 2098233..2098559 - 327 WP_001052491.1 anti-sigma factor antagonist -
QPR40_RS10375 (QPR40_10375) 2098678..2099679 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QPR40_RS10380 (QPR40_10380) 2100029..2100391 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QPR40_RS10385 (QPR40_10385) 2100388..2100558 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QPR40_RS10390 (QPR40_10390) 2100643..2101791 - 1149 WP_001281154.1 alanine racemase -
QPR40_RS10395 (QPR40_10395) 2101857..2102216 - 360 WP_000581197.1 holo-ACP synthase -
QPR40_RS10400 (QPR40_10400) 2102220..2102711 - 492 WP_001205912.1 PH domain-containing protein -
QPR40_RS10405 (QPR40_10405) 2102698..2104281 - 1584 WP_001294622.1 PH domain-containing protein -
QPR40_RS10410 (QPR40_10410) 2104274..2104753 - 480 WP_001287079.1 hypothetical protein -
QPR40_RS10415 (QPR40_10415) 2104962..2105522 - 561 WP_285144186.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T282972 WP_000621175.1 NZ_CP126627:c2100391-2100029 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT282972 WP_000948331.1 NZ_CP126627:c2100558-2100388 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References