282971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1917230..1918006 Replicon chromosome
Accession NZ_CP126627
Organism Staphylococcus aureus strain 17-21

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QPR40_RS09310 Protein ID WP_000031108.1
Coordinates 1917230..1917382 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QPR40_RS09315 Protein ID WP_001251224.1
Coordinates 1917407..1918006 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR40_RS09295 (QPR40_09295) 1913437..1914258 + 822 WP_000669376.1 RluA family pseudouridine synthase -
QPR40_RS09300 (QPR40_09300) 1914710..1916095 - 1386 WP_285144106.1 class II fumarate hydratase -
QPR40_RS09305 (QPR40_09305) 1916291..1916686 - 396 WP_000901023.1 hypothetical protein -
QPR40_RS09310 (QPR40_09310) 1917230..1917382 - 153 WP_000031108.1 SAS053 family protein Toxin
QPR40_RS09315 (QPR40_09315) 1917407..1918006 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QPR40_RS09320 (QPR40_09320) 1918165..1918635 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QPR40_RS09325 (QPR40_09325) 1918640..1919767 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
QPR40_RS09330 (QPR40_09330) 1919919..1920641 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QPR40_RS09335 (QPR40_09335) 1920634..1922091 - 1458 WP_285144108.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282971 WP_000031108.1 NZ_CP126627:c1917382-1917230 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT282971 WP_001251224.1 NZ_CP126627:c1918006-1917407 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References