Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 557936..558572 Replicon chromosome
Accession NZ_CP126576
Organism Bacillus licheniformis strain CQMB003

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QPK28_RS02775 Protein ID WP_003179128.1
Coordinates 558222..558572 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QPK28_RS02770 Protein ID WP_006638778.1
Coordinates 557936..558217 (+) Length 94 a.a.

Genomic Context

QPK28_RS02750QPK28_RS02760QPK28_RS02765QPK28_RS02770QPK28_RS02775QPK28_RS02780QPK28_RS02785QPK28_RS02790QPK28_RS02795QPK28_RS02800QPK28_RS02805QPK28_RS02810QPK28_RS02815QPK28_RS02755
Location: 553051..554532 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 555471..556430 (960 bp)
Type: Others
Protein ID: WP_152847888.1
Location: 556655..557824 (1170 bp)
Type: Others
Protein ID: WP_025807384.1
Location: 557936..558217 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 558222..558572 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 558690..559517 (828 bp)
Type: Others
Protein ID: WP_003179130.1
Location: 559521..559886 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 559889..560290 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 560301..561308 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 561367..561693 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 561693..562178 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 562144..562935 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 562932..563531 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 554529..555128 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QPK28_RS02750553051..554532+1482WP_009330132.1PH domain-containing protein-
QPK28_RS02755554529..555128-600WP_003179118.1rhomboid family intramembrane serine protease-
QPK28_RS02760555471..556430+960WP_152847888.1outer membrane lipoprotein carrier protein LolA-
QPK28_RS02765556655..557824+1170WP_025807384.1alanine racemase-
QPK28_RS02770557936..558217+282WP_006638778.1hypothetical proteinAntitoxin
QPK28_RS02775558222..558572+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
QPK28_RS02780558690..559517+828WP_003179130.1RsbT co-antagonist protein RsbRA-
QPK28_RS02785559521..559886+366WP_003179132.1STAS domain-containing protein-
QPK28_RS02790559889..560290+402WP_003179135.1anti-sigma regulatory factor-
QPK28_RS02795560301..561308+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
QPK28_RS02800561367..561693+327WP_003179140.1anti-sigma factor antagonist-
QPK28_RS02805561693..562178+486WP_003179142.1anti-sigma B factor RsbW-
QPK28_RS02810562144..562935+792WP_003179144.1RNA polymerase sigma factor SigB-
QPK28_RS02815562932..563531+600WP_003179145.1PP2C family serine/threonine-protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T282968 WP_003179128.1 NZ_CP126576:558222-558572 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT282968 WP_006638778.1 NZ_CP126576:557936-558217 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References