Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 557936..558572 Replicon chromosome
Accession NZ_CP126576
Organism Bacillus licheniformis strain CQMB003

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QPK28_RS02775 Protein ID WP_003179128.1
Coordinates 558222..558572 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QPK28_RS02770 Protein ID WP_006638778.1
Coordinates 557936..558217 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPK28_RS02750 553051..554532 + 1482 WP_009330132.1 PH domain-containing protein -
QPK28_RS02755 554529..555128 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
QPK28_RS02760 555471..556430 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
QPK28_RS02765 556655..557824 + 1170 WP_025807384.1 alanine racemase -
QPK28_RS02770 557936..558217 + 282 WP_006638778.1 hypothetical protein Antitoxin
QPK28_RS02775 558222..558572 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPK28_RS02780 558690..559517 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
QPK28_RS02785 559521..559886 + 366 WP_003179132.1 STAS domain-containing protein -
QPK28_RS02790 559889..560290 + 402 WP_003179135.1 anti-sigma regulatory factor -
QPK28_RS02795 560301..561308 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
QPK28_RS02800 561367..561693 + 327 WP_003179140.1 anti-sigma factor antagonist -
QPK28_RS02805 561693..562178 + 486 WP_003179142.1 anti-sigma B factor RsbW -
QPK28_RS02810 562144..562935 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
QPK28_RS02815 562932..563531 + 600 WP_003179145.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T282968 WP_003179128.1 NZ_CP126576:558222-558572 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT282968 WP_006638778.1 NZ_CP126576:557936-558217 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References