282961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 950653..951182 Replicon chromosome
Accession NZ_CP126540
Organism Staphylococcus cohnii strain SDAQ-1

Toxin (Protein)


Gene name mazF Uniprot ID A0A6N7XWP7
Locus tag QMK35_RS04395 Protein ID WP_019468010.1
Coordinates 950820..951182 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6N7Y6B0
Locus tag QMK35_RS04390 Protein ID WP_019468009.1
Coordinates 950653..950823 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK35_RS04365 (QMK35_04365) 946464..946943 + 480 WP_107384543.1 PH domain-containing protein -
QMK35_RS04370 (QMK35_04370) 946936..948441 + 1506 WP_107384542.1 PH domain-containing protein -
QMK35_RS04375 (QMK35_04375) 948434..948925 + 492 WP_107384541.1 PH domain-containing protein -
QMK35_RS04380 (QMK35_04380) 948961..949311 + 351 WP_107384540.1 holo-ACP synthase -
QMK35_RS04385 (QMK35_04385) 949417..950565 + 1149 WP_107386317.1 alanine racemase -
QMK35_RS04390 (QMK35_04390) 950653..950823 + 171 WP_019468009.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QMK35_RS04395 (QMK35_04395) 950820..951182 + 363 WP_019468010.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMK35_RS04400 (QMK35_04400) 951526..952527 + 1002 WP_107384538.1 PP2C family protein-serine/threonine phosphatase -
QMK35_RS04405 (QMK35_04405) 952596..952922 + 327 WP_019468012.1 anti-sigma factor antagonist -
QMK35_RS04410 (QMK35_04410) 952924..953406 + 483 WP_019468013.1 anti-sigma B factor RsbW -
QMK35_RS04415 (QMK35_04415) 953381..954151 + 771 WP_107384537.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13595.69 Da        Isoelectric Point: 9.9426

>T282961 WP_019468010.1 NZ_CP126540:950820-951182 [Staphylococcus cohnii]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEEKMQEVNNAIDISLGLHNIRNHRT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6359.02 Da        Isoelectric Point: 4.0121

>AT282961 WP_019468009.1 NZ_CP126540:950653-950823 [Staphylococcus cohnii]
MASFNQNRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYIISKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N7XWP7

Antitoxin

Source ID Structure
AlphaFold DB A0A6N7Y6B0

References