Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 939088..939602 Replicon chromosome
Accession NZ_CP126540
Organism Staphylococcus cohnii strain SDAQ-1

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag QMK35_RS04335 Protein ID WP_107384548.1
Coordinates 939396..939602 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag QMK35_RS04330 Protein ID WP_107384549.1
Coordinates 939088..939381 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK35_RS04305 (QMK35_04305) 934320..934958 + 639 WP_285159877.1 thiamine phosphate synthase -
QMK35_RS04310 (QMK35_04310) 935045..935914 + 870 WP_107385189.1 membrane protein insertase YidC -
QMK35_RS04315 (QMK35_04315) 936083..936266 - 184 Protein_851 IS5/IS1182 family transposase -
QMK35_RS04320 (QMK35_04320) 936544..937188 - 645 WP_285159878.1 HD domain-containing protein -
QMK35_RS04325 (QMK35_04325) 937462..938946 - 1485 WP_107504822.1 cardiolipin synthase -
QMK35_RS04330 (QMK35_04330) 939088..939381 + 294 WP_107384549.1 copper-sensing transcriptional repressor CsoR Antitoxin
QMK35_RS04335 (QMK35_04335) 939396..939602 + 207 WP_107384548.1 heavy metal-associated domain-containing protein Toxin
QMK35_RS04340 (QMK35_04340) 939860..940000 + 141 WP_002482742.1 Lmo0850 family protein -
QMK35_RS04345 (QMK35_04345) 940438..941625 - 1188 WP_107384547.1 FtsW/RodA/SpoVE family cell cycle protein -
QMK35_RS04350 (QMK35_04350) 941885..942955 + 1071 WP_107384546.1 D-alanine--D-alanine ligase -
QMK35_RS04355 (QMK35_04355) 942968..944323 + 1356 WP_107384545.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7935.12 Da        Isoelectric Point: 4.4778

>T282960 WP_107384548.1 NZ_CP126540:939396-939602 [Staphylococcus cohnii]
MESQIIYLSKINHKQDKLQIENKLSQIIGVNHVLVDIEKAQVFIEFETPASLNNLEKDIYDLGFEILY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11182.83 Da        Isoelectric Point: 6.8617

>AT282960 WP_107384549.1 NZ_CP126540:939088-939381 [Staphylococcus cohnii]
MAELQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References