Detailed information of TA system TA282960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 939088..939602
• Replicon: chromosome
• Accession: NZ_CP126540
• Organism: Staphylococcus cohnii strain SDAQ-1

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: QMK35_RS04335
• Protein ID: WP_107384548.1
• Coordinates: 939396..939602 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: QMK35_RS04330
• Protein ID: WP_107384549.1
• Coordinates: 939088..939381 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMK35_RS04305 (QMK35_04305)	934320..934958	+	639	WP_285159877.1	thiamine phosphate synthase	-
QMK35_RS04310 (QMK35_04310)	935045..935914	+	870	WP_107385189.1	membrane protein insertase YidC	-
QMK35_RS04315 (QMK35_04315)	936083..936266	-	184	Protein_851	IS5/IS1182 family transposase	-
QMK35_RS04320 (QMK35_04320)	936544..937188	-	645	WP_285159878.1	HD domain-containing protein	-
QMK35_RS04325 (QMK35_04325)	937462..938946	-	1485	WP_107504822.1	cardiolipin synthase	-
QMK35_RS04330 (QMK35_04330)	939088..939381	+	294	WP_107384549.1	copper-sensing transcriptional repressor CsoR	Antitoxin
QMK35_RS04335 (QMK35_04335)	939396..939602	+	207	WP_107384548.1	heavy metal-associated domain-containing protein	Toxin
QMK35_RS04340 (QMK35_04340)	939860..940000	+	141	WP_002482742.1	Lmo0850 family protein	-
QMK35_RS04345 (QMK35_04345)	940438..941625	-	1188	WP_107384547.1	FtsW/RodA/SpoVE family cell cycle protein	-
QMK35_RS04350 (QMK35_04350)	941885..942955	+	1071	WP_107384546.1	D-alanine--D-alanine ligase	-
QMK35_RS04355 (QMK35_04355)	942968..944323	+	1356	WP_107384545.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (20-65)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7935.12 Da
• Isoelectric Point: 4.4778

>T282960 WP_107384548.1 NZ_CP126540:939396-939602 [Staphylococcus cohnii]
MESQIIYLSKINHKQDKLQIENKLSQIIGVNHVLVDIEKAQVFIEFETPASLNNLEKDIYDLGFEILY

Nucleotide

• Length: 207 bp

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11182.83 Da
• Isoelectric Point: 6.8617

>AT282960 WP_107384549.1 NZ_CP126540:939088-939381 [Staphylococcus cohnii]
MAELQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Nucleotide

• Length: 294 bp