Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4958901..4959567 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag QOK75_RS24635 Protein ID WP_134214823.1
Coordinates 4959208..4959567 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag QOK75_RS24630 Protein ID WP_134214821.1
Coordinates 4958901..4959218 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS24590 (4954312) 4954312..4954629 - 318 WP_054527950.1 CcdB family protein -
QOK75_RS24595 (4954629) 4954629..4954922 - 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
QOK75_RS24600 (4955019) 4955019..4955384 - 366 WP_134214819.1 hypothetical protein -
QOK75_RS24605 (4955516) 4955516..4955689 + 174 WP_032938222.1 hypothetical protein -
QOK75_RS24610 (4955823) 4955823..4956077 + 255 Protein_4827 transposase -
QOK75_RS24615 (4956308) 4956308..4957648 + 1341 WP_008786676.1 IS110 family transposase -
QOK75_RS24620 (4957662) 4957662..4958579 + 918 Protein_4829 IS3 family transposase -
QOK75_RS24625 (4958600) 4958600..4958761 + 162 WP_003841416.1 phage protein -
QOK75_RS24630 (4958901) 4958901..4959218 - 318 WP_134214821.1 helix-turn-helix transcriptional regulator Antitoxin
QOK75_RS24635 (4959208) 4959208..4959567 - 360 WP_134214823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOK75_RS24640 (4959781) 4959781..4960470 + 690 WP_003841421.1 dipeptidase PepE -
QOK75_RS24645 (4960617) 4960617..4962248 - 1632 WP_134214825.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13456.53 Da        Isoelectric Point: 10.2555

>T282953 WP_134214823.1 NZ_CP126536:c4959567-4959208 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFAFWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11504.44 Da        Isoelectric Point: 8.9375

>AT282953 WP_134214821.1 NZ_CP126536:c4959218-4958901 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References