Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4501432..4501948 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag QOK75_RS22170 Protein ID WP_003839578.1
Coordinates 4501432..4501716 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QOK75_RS22175 Protein ID WP_134216310.1
Coordinates 4501706..4501948 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS22155 (4497757) 4497757..4498341 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
QOK75_RS22160 (4498719) 4498719..4500857 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
QOK75_RS22165 (4500964) 4500964..4501428 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QOK75_RS22170 (4501432) 4501432..4501716 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QOK75_RS22175 (4501706) 4501706..4501948 - 243 WP_134216310.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QOK75_RS22180 (4502026) 4502026..4503939 - 1914 WP_134216312.1 BglG family transcription antiterminator -
QOK75_RS22185 (4503961) 4503961..4504701 - 741 WP_048216922.1 KDGP aldolase family protein -
QOK75_RS22190 (4504698) 4504698..4505816 - 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QOK75_RS22195 (4505800) 4505800..4506933 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T282950 WP_003839578.1 NZ_CP126536:c4501716-4501432 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8963.38 Da        Isoelectric Point: 5.0649

>AT282950 WP_134216310.1 NZ_CP126536:c4501948-4501706 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPSEAVRLLFQYVAETGRMPVKTVTVSDCEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure

References