Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4432410..4433131 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag QOK75_RS21845 Protein ID WP_063149808.1
Coordinates 4432410..4432751 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QOK75_RS21850 Protein ID WP_080460847.1
Coordinates 4432787..4433131 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS21815 (4428426) 4428426..4428788 + 363 WP_003837149.1 endoribonuclease SymE -
QOK75_RS21820 (4428947) 4428947..4429819 + 873 WP_134216258.1 HNH endonuclease -
QOK75_RS21825 (4429948) 4429948..4430742 - 795 WP_134216261.1 helix-turn-helix transcriptional regulator -
QOK75_RS21830 (4430858) 4430858..4431133 - 276 WP_063149810.1 type II toxin-antitoxin system RelE/ParE family toxin -
QOK75_RS21835 (4431137) 4431137..4431385 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein -
QOK75_RS21840 (4431462) 4431462..4432295 - 834 WP_063149809.1 DUF4942 domain-containing protein -
QOK75_RS21845 (4432410) 4432410..4432751 - 342 WP_063149808.1 TA system toxin CbtA family protein Toxin
QOK75_RS21850 (4432787) 4432787..4433131 - 345 WP_080460847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QOK75_RS21855 (4433155) 4433155..4433376 - 222 WP_063149807.1 DUF987 family protein -
QOK75_RS21860 (4433324) 4433324..4433860 - 537 WP_080460846.1 DNA repair protein RadC -
QOK75_RS21865 (4433930) 4433930..4434748 - 819 WP_172616074.1 DUF932 domain-containing protein -
QOK75_RS21870 (4434888) 4434888..4435139 - 252 WP_063149806.1 DUF905 family protein -
QOK75_RS21875 (4435136) 4435136..4435807 - 672 WP_063149805.1 hypothetical protein -
QOK75_RS21880 (4435990) 4435990..4436379 - 390 WP_063149804.1 hypothetical protein -
QOK75_RS21885 (4436376) 4436376..4437098 - 723 WP_232051960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12865.79 Da        Isoelectric Point: 9.8519

>T282949 WP_063149808.1 NZ_CP126536:c4432751-4432410 [Citrobacter freundii]
MKAFPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLTLNDTPFNDESVIQEHINAGITLADAVNFLVEKNELVRIDRRGF
SWQEQSPYLRAVDILRARQATGLLRQSHNLLTR

Download         Length: 342 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13074.13 Da        Isoelectric Point: 8.7074

>AT282949 WP_080460847.1 NZ_CP126536:c4433131-4432787 [Citrobacter freundii]
MKKDTANEVMDTLQWGLKCDITPHFGARLAQEGNRLHYLADRASIIGQFSKADLRHLNQAFPLLMKHMELMLTSGELNPR
HQHRVTLYAKRLTCEVDTLGSCGYVYIAIYPTQR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References