Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3818348..3818968 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QOK75_RS18985 Protein ID WP_002892050.1
Coordinates 3818750..3818968 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag QOK75_RS18980 Protein ID WP_003021733.1
Coordinates 3818348..3818722 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS18970 (3813494) 3813494..3814687 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QOK75_RS18975 (3814710) 3814710..3817859 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
QOK75_RS18980 (3818348) 3818348..3818722 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
QOK75_RS18985 (3818750) 3818750..3818968 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QOK75_RS18990 (3819275) 3819275..3819826 + 552 WP_134216077.1 maltose O-acetyltransferase -
QOK75_RS18995 (3819943) 3819943..3820413 + 471 WP_003021724.1 YlaC family protein -
QOK75_RS19000 (3820492) 3820492..3820632 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
QOK75_RS19005 (3820634) 3820634..3820894 - 261 WP_003835926.1 type B 50S ribosomal protein L31 -
QOK75_RS19010 (3821083) 3821083..3822636 + 1554 WP_142710219.1 EAL domain-containing protein -
QOK75_RS19015 (3822688) 3822688..3823041 - 354 WP_003831033.1 DUF1428 family protein -
QOK75_RS19020 (3823106) 3823106..3823735 - 630 WP_016149709.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282947 WP_002892050.1 NZ_CP126536:3818750-3818968 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT282947 WP_003021733.1 NZ_CP126536:3818348-3818722 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References