Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3088114..3088704 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name pemK Uniprot ID A0A0J1NBD3
Locus tag QOK75_RS15365 Protein ID WP_003836692.1
Coordinates 3088114..3088446 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0J1NBD4
Locus tag QOK75_RS15370 Protein ID WP_003836694.1
Coordinates 3088447..3088704 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS15340 (3083867) 3083867..3085354 + 1488 WP_003846749.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
QOK75_RS15350 (3085670) 3085670..3086620 - 951 WP_134215814.1 HTH-type transcriptional regulator Cbl -
QOK75_RS15355 (3086722) 3086722..3087639 - 918 WP_003030855.1 nitrogen assimilation transcriptional regulator NAC -
QOK75_RS15365 (3088114) 3088114..3088446 - 333 WP_003836692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QOK75_RS15370 (3088447) 3088447..3088704 - 258 WP_003836694.1 hypothetical protein Antitoxin
QOK75_RS15375 (3089318) 3089318..3093217 + 3900 WP_240210323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 8.5572

>T282946 WP_003836692.1 NZ_CP126536:c3088446-3088114 [Citrobacter freundii]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9428.89 Da        Isoelectric Point: 4.3440

>AT282946 WP_003836694.1 NZ_CP126536:c3088704-3088447 [Citrobacter freundii]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NBD3

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1NBD4

References