Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2873740..2874379 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name hicA Uniprot ID A0A8B5QF36
Locus tag QOK75_RS14260 Protein ID WP_003020221.1
Coordinates 2874203..2874379 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QOK75_RS14255 Protein ID WP_123924900.1
Coordinates 2873740..2874156 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS14235 (2868786) 2868786..2869730 - 945 WP_003843727.1 ABC transporter permease -
QOK75_RS14240 (2869731) 2869731..2870747 - 1017 WP_058842662.1 ABC transporter ATP-binding protein -
QOK75_RS14245 (2870764) 2870764..2871909 - 1146 WP_134215522.1 ABC transporter substrate-binding protein -
QOK75_RS14250 (2872238) 2872238..2873647 - 1410 WP_134215520.1 PLP-dependent aminotransferase family protein -
QOK75_RS14255 (2873740) 2873740..2874156 - 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QOK75_RS14260 (2874203) 2874203..2874379 - 177 WP_003020221.1 type II toxin-antitoxin system HicA family toxin Toxin
QOK75_RS14265 (2874643) 2874643..2876046 + 1404 WP_003020224.1 cytochrome ubiquinol oxidase subunit I -
QOK75_RS14270 (2876046) 2876046..2877056 + 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
QOK75_RS14275 (2877056) 2877056..2877181 + 126 WP_003020230.1 DUF2474 domain-containing protein -
QOK75_RS14280 (2877371) 2877371..2877601 + 231 WP_003020233.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6769.80 Da        Isoelectric Point: 11.2510

>T282945 WP_003020221.1 NZ_CP126536:c2874379-2874203 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT282945 WP_123924900.1 NZ_CP126536:c2874156-2873740 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QF36

Antitoxin

Source ID Structure

References