Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 944977..945631 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag QOK75_RS04720 Protein ID WP_003026936.1
Coordinates 945224..945631 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag QOK75_RS04715 Protein ID WP_003026938.1
Coordinates 944977..945243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS04690 (940178) 940178..941611 - 1434 WP_003838263.1 6-phospho-beta-glucosidase BglA -
QOK75_RS04695 (941732) 941732..942460 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
QOK75_RS04700 (942513) 942513..942824 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
QOK75_RS04705 (942987) 942987..943646 + 660 WP_003838267.1 hemolysin III family protein -
QOK75_RS04710 (943740) 943740..944720 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
QOK75_RS04715 (944977) 944977..945243 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
QOK75_RS04720 (945224) 945224..945631 + 408 WP_003026936.1 protein YgfX Toxin
QOK75_RS04725 (945676) 945676..946197 - 522 WP_003026933.1 flavodoxin FldB -
QOK75_RS04730 (946311) 946311..947207 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
QOK75_RS04735 (947231) 947231..947944 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QOK75_RS04740 (947950) 947950..949683 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T282940 WP_003026936.1 NZ_CP126536:945224-945631 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT282940 WP_003026938.1 NZ_CP126536:944977-945243 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References