Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 353104..353735 Replicon chromosome
Accession NZ_CP126536
Organism Citrobacter freundii strain CRNMS1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag QOK75_RS01690 Protein ID WP_003837806.1
Coordinates 353104..353379 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag QOK75_RS01695 Protein ID WP_003837808.1
Coordinates 353376..353735 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOK75_RS01680 (349155) 349155..351902 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
QOK75_RS01685 (351902) 351902..353026 + 1125 WP_003837801.1 ABC transporter permease -
QOK75_RS01690 (353104) 353104..353379 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
QOK75_RS01695 (353376) 353376..353735 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QOK75_RS01700 (353846) 353846..354247 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
QOK75_RS01705 (354297) 354297..354875 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
QOK75_RS01710 (354938) 354938..355987 - 1050 WP_003023393.1 AI-2E family transporter -
QOK75_RS01715 (356121) 356121..357338 + 1218 WP_032950436.1 MFS transporter -
QOK75_RS01720 (357342) 357342..357899 - 558 WP_003837816.1 DcrB family lipoprotein -
QOK75_RS01725 (357972) 357972..358637 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T282937 WP_003837806.1 NZ_CP126536:353104-353379 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT282937 WP_003837808.1 NZ_CP126536:353376-353735 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References