Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1629599..1630234 Replicon chromosome
Accession NZ_CP126535
Organism Paenibacillus sp. PK1-4R

Toxin (Protein)


Gene name mazF Uniprot ID W4B4V0
Locus tag QNO02_RS06795 Protein ID WP_024630714.1
Coordinates 1629884..1630234 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W4B5R5
Locus tag QNO02_RS06790 Protein ID WP_017690037.1
Coordinates 1629599..1629880 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNO02_RS06770 (QNO02_06770) 1624814..1625926 - 1113 WP_289391520.1 serine hydrolase -
QNO02_RS06775 (QNO02_06775) 1625827..1626306 - 480 WP_289391521.1 serine hydrolase -
QNO02_RS06780 (QNO02_06780) 1626556..1627755 + 1200 WP_289391522.1 DUF4367 domain-containing protein -
QNO02_RS06785 (QNO02_06785) 1628151..1629338 + 1188 WP_091033662.1 alanine racemase -
QNO02_RS06790 (QNO02_06790) 1629599..1629880 + 282 WP_017690037.1 ribbon-helix-helix protein, CopG family Antitoxin
QNO02_RS06795 (QNO02_06795) 1629884..1630234 + 351 WP_024630714.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNO02_RS06800 (QNO02_06800) 1630472..1632661 + 2190 WP_289391523.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12778.77 Da        Isoelectric Point: 5.1184

>T282935 WP_024630714.1 NZ_CP126535:1629884-1630234 [Paenibacillus sp. PK1-4R]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTCIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKLVNEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10737.36 Da        Isoelectric Point: 5.8649

>AT282935 WP_017690037.1 NZ_CP126535:1629599-1629880 [Paenibacillus sp. PK1-4R]
VANLQNTKRIMISLPDYLLQEVDGIVALENSNRSELIRQAMKLYLTERKKRYIRETMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W4B4V0

Antitoxin

Source ID Structure
AlphaFold DB W4B5R5

References