Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3208442..3209078 Replicon chromosome
Accession NZ_CP126534
Organism Bacillus inaquosorum strain BSY82

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QN218_RS16300 Protein ID WP_003156187.1
Coordinates 3208442..3208792 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QN218_RS16305 Protein ID WP_003225183.1
Coordinates 3208797..3209078 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN218_RS16260 3203486..3204085 - 600 WP_060397967.1 phosphoserine phosphatase RsbX -
QN218_RS16265 3204085..3204873 - 789 WP_003240361.1 RNA polymerase sigma factor SigB -
QN218_RS16270 3204839..3205321 - 483 WP_003240359.1 anti-sigma B factor RsbW -
QN218_RS16275 3205318..3205647 - 330 WP_003240357.1 anti-sigma factor antagonist RsbV -
QN218_RS16280 3205709..3206716 - 1008 WP_003240354.1 phosphoserine phosphatase RsbU -
QN218_RS16285 3206728..3207129 - 402 WP_003240352.1 serine/threonine-protein kinase RsbT -
QN218_RS16290 3207133..3207498 - 366 WP_003225190.1 RsbT antagonist protein RsbS -
QN218_RS16295 3207503..3208327 - 825 WP_003240350.1 RsbT co-antagonist protein RsbRA -
QN218_RS16300 3208442..3208792 - 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QN218_RS16305 3208797..3209078 - 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QN218_RS16310 3209193..3210362 - 1170 WP_060397966.1 alanine racemase -
QN218_RS16315 3210477..3211493 - 1017 WP_080010740.1 outer membrane lipoprotein carrier protein LolA -
QN218_RS16320 3211658..3212023 - 366 WP_003240339.1 holo-ACP synthase -
QN218_RS16325 3212118..3212717 + 600 WP_003240338.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T282934 WP_003156187.1 NZ_CP126534:c3208792-3208442 [Bacillus inaquosorum]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT282934 WP_003225183.1 NZ_CP126534:c3209078-3208797 [Bacillus inaquosorum]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References