Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 526456..527092 Replicon chromosome
Accession NZ_CP126530
Organism Bacillus halotolerans strain Tehuacan_S4

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QPL78_RS02675 Protein ID WP_003156187.1
Coordinates 526742..527092 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QPL78_RS02670 Protein ID WP_003225183.1
Coordinates 526456..526737 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL78_RS02650 (QPL78_02650) 522811..523410 - 600 WP_024120294.1 rhomboid family intramembrane serine protease -
QPL78_RS02655 (QPL78_02655) 523505..523870 + 366 WP_101864032.1 holo-ACP synthase -
QPL78_RS02660 (QPL78_02660) 524036..525052 + 1017 WP_284560745.1 outer membrane lipoprotein carrier protein LolA -
QPL78_RS02665 (QPL78_02665) 525169..526338 + 1170 WP_284560212.1 alanine racemase -
QPL78_RS02670 (QPL78_02670) 526456..526737 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QPL78_RS02675 (QPL78_02675) 526742..527092 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPL78_RS02680 (QPL78_02680) 527207..528031 + 825 WP_081638235.1 RsbT co-antagonist protein RsbRA -
QPL78_RS02685 (QPL78_02685) 528036..528401 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QPL78_RS02690 (QPL78_02690) 528405..528806 + 402 WP_024120299.1 serine/threonine-protein kinase RsbT -
QPL78_RS02695 (QPL78_02695) 528818..529825 + 1008 WP_024120300.1 phosphoserine phosphatase RsbU -
QPL78_RS02700 (QPL78_02700) 529886..530215 + 330 WP_024120301.1 anti-sigma factor antagonist RsbV -
QPL78_RS02705 (QPL78_02705) 530212..530694 + 483 WP_024120302.1 anti-sigma B factor RsbW -
QPL78_RS02710 (QPL78_02710) 530660..531448 + 789 WP_024120303.1 RNA polymerase sigma factor SigB -
QPL78_RS02715 (QPL78_02715) 531448..532047 + 600 WP_024120304.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T282931 WP_003156187.1 NZ_CP126530:526742-527092 [Bacillus halotolerans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT282931 WP_003225183.1 NZ_CP126530:526456-526737 [Bacillus halotolerans]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References