Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2312318..2313296 Replicon chromosome
Accession NZ_CP126525
Organism Bacillus toyonensis strain Puebla_S2

Toxin (Protein)


Gene name spoIISA Uniprot ID K0FNW8
Locus tag QPL84_RS11855 Protein ID WP_000155917.1
Coordinates 2312318..2313058 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID J8KE32
Locus tag QPL84_RS11860 Protein ID WP_000588713.1
Coordinates 2313171..2313296 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL84_RS11835 (QPL84_11835) 2307980..2308762 + 783 WP_185777487.1 class I SAM-dependent methyltransferase -
QPL84_RS11840 (QPL84_11840) 2308941..2310617 - 1677 WP_284558607.1 alpha-keto acid decarboxylase family protein -
QPL84_RS11845 (QPL84_11845) 2310744..2311226 + 483 WP_000191892.1 MarR family winged helix-turn-helix transcriptional regulator -
QPL84_RS11850 (QPL84_11850) 2311394..2312131 + 738 WP_000594132.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QPL84_RS11855 (QPL84_11855) 2312318..2313058 + 741 WP_000155917.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QPL84_RS11860 (QPL84_11860) 2313171..2313296 + 126 WP_000588713.1 hypothetical protein Antitoxin
QPL84_RS11865 (QPL84_11865) 2313372..2313548 + 177 WP_000808012.1 stage II sporulation protein SB -
QPL84_RS11870 (QPL84_11870) 2313597..2313986 - 390 WP_284558608.1 YxeA family protein -
QPL84_RS11875 (QPL84_11875) 2314230..2315699 + 1470 WP_284558609.1 beta-Ala-His dipeptidase -
QPL84_RS11880 (QPL84_11880) 2316010..2316819 + 810 WP_000678381.1 papain-like cysteine protease family protein -
QPL84_RS11885 (QPL84_11885) 2316847..2317449 + 603 WP_000517300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28446.03 Da        Isoelectric Point: 7.3946

>T282930 WP_000155917.1 NZ_CP126525:2312318-2313058 [Bacillus toyonensis]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4951.43 Da        Isoelectric Point: 4.1079

>AT282930 WP_000588713.1 NZ_CP126525:2313171-2313296 [Bacillus toyonensis]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0FNW8

Antitoxin

Source ID Structure
AlphaFold DB J8KE32

References