Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 238573..239215 Replicon chromosome
Accession NZ_CP126525
Organism Bacillus toyonensis strain Puebla_S2

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QPL84_RS01370 Protein ID WP_000635963.1
Coordinates 238865..239215 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QPL84_RS01365 Protein ID WP_000004570.1
Coordinates 238573..238860 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL84_RS01340 (QPL84_01340) 233900..234862 + 963 WP_000961174.1 UV DNA damage repair endonuclease UvsE -
QPL84_RS01345 (QPL84_01345) 234855..235427 - 573 WP_000908503.1 rhomboid family intramembrane serine protease -
QPL84_RS01350 (QPL84_01350) 235520..235879 + 360 WP_000635048.1 holo-ACP synthase -
QPL84_RS01355 (QPL84_01355) 236036..236986 + 951 WP_002037834.1 outer membrane lipoprotein carrier protein LolA -
QPL84_RS01360 (QPL84_01360) 237104..238273 + 1170 WP_000390621.1 alanine racemase -
QPL84_RS01365 (QPL84_01365) 238573..238860 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QPL84_RS01370 (QPL84_01370) 238865..239215 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPL84_RS01375 (QPL84_01375) 239284..241452 + 2169 WP_141495663.1 Tex family protein -
QPL84_RS01380 (QPL84_01380) 241511..241627 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QPL84_RS01385 (QPL84_01385) 241835..242311 + 477 WP_097838208.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282929 WP_000635963.1 NZ_CP126525:238865-239215 [Bacillus toyonensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282929 WP_000004570.1 NZ_CP126525:238573-238860 [Bacillus toyonensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References