Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 238273..238915 Replicon chromosome
Accession NZ_CP126524
Organism Bacillus toyonensis strain Monterrey_S3

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QPL83_RS02990 Protein ID WP_000635963.1
Coordinates 238565..238915 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QPL83_RS02985 Protein ID WP_000004570.1
Coordinates 238273..238560 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL83_RS02960 (QPL83_02960) 233600..234562 + 963 WP_000961174.1 UV DNA damage repair endonuclease UvsE -
QPL83_RS02965 (QPL83_02965) 234555..235127 - 573 WP_000908503.1 rhomboid family intramembrane serine protease -
QPL83_RS02970 (QPL83_02970) 235220..235579 + 360 WP_000635048.1 holo-ACP synthase -
QPL83_RS02975 (QPL83_02975) 235736..236686 + 951 WP_002037834.1 outer membrane lipoprotein carrier protein LolA -
QPL83_RS02980 (QPL83_02980) 236804..237973 + 1170 WP_000390621.1 alanine racemase -
QPL83_RS02985 (QPL83_02985) 238273..238560 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QPL83_RS02990 (QPL83_02990) 238565..238915 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPL83_RS02995 (QPL83_02995) 238984..241152 + 2169 WP_000426215.1 Tex family protein -
QPL83_RS03000 (QPL83_03000) 241211..241327 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QPL83_RS03005 (QPL83_03005) 241535..242002 + 468 WP_000544525.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282927 WP_000635963.1 NZ_CP126524:238565-238915 [Bacillus toyonensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282927 WP_000004570.1 NZ_CP126524:238273-238560 [Bacillus toyonensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References