Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 521418..522054 Replicon chromosome
Accession NZ_CP126521
Organism Bacillus pumilus strain Monterrey_S2

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QPL77_RS02510 Protein ID WP_003214169.1
Coordinates 521704..522054 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A267X601
Locus tag QPL77_RS02505 Protein ID WP_012008995.1
Coordinates 521418..521699 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL77_RS02485 (QPL77_02485) 517398..518003 - 606 WP_144522255.1 rhomboid family intramembrane serine protease -
QPL77_RS02490 (QPL77_02490) 518098..518463 + 366 WP_211063298.1 holo-ACP synthase -
QPL77_RS02495 (QPL77_02495) 518624..519640 + 1017 WP_088004450.1 outer membrane lipoprotein carrier protein LolA -
QPL77_RS02500 (QPL77_02500) 519943..521121 + 1179 WP_211063297.1 alanine racemase -
QPL77_RS02505 (QPL77_02505) 521418..521699 + 282 WP_012008995.1 hypothetical protein Antitoxin
QPL77_RS02510 (QPL77_02510) 521704..522054 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPL77_RS02515 (QPL77_02515) 522169..522999 + 831 WP_012008996.1 RsbT co-antagonist protein RsbRA -
QPL77_RS02520 (QPL77_02520) 523004..523372 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QPL77_RS02525 (QPL77_02525) 523375..523776 + 402 WP_003214085.1 anti-sigma regulatory factor -
QPL77_RS02530 (QPL77_02530) 523787..524794 + 1008 WP_144522260.1 PP2C family protein-serine/threonine phosphatase -
QPL77_RS02535 (QPL77_02535) 524854..525183 + 330 WP_012008998.1 anti-sigma factor antagonist -
QPL77_RS02540 (QPL77_02540) 525180..525668 + 489 WP_012008999.1 anti-sigma B factor RsbW -
QPL77_RS02545 (QPL77_02545) 525634..526422 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
QPL77_RS02550 (QPL77_02550) 526422..527021 + 600 WP_211063296.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T282926 WP_003214169.1 NZ_CP126521:521704-522054 [Bacillus pumilus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10894.27 Da        Isoelectric Point: 5.2726

>AT282926 WP_012008995.1 NZ_CP126521:521418-521699 [Bacillus pumilus]
MSESSATNEMKIRLPETLMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A267X601

References