Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2320427..2321405 Replicon chromosome
Accession NZ_CP126520
Organism Bacillus toyonensis strain Cuernavaca_S4

Toxin (Protein)


Gene name spoIISA Uniprot ID K0FNW8
Locus tag QPL81_RS14125 Protein ID WP_000155917.1
Coordinates 2320427..2321167 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID J8KE32
Locus tag QPL81_RS14130 Protein ID WP_000588713.1
Coordinates 2321280..2321405 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL81_RS14105 (QPL81_14105) 2316087..2316869 + 783 WP_000381781.1 class I SAM-dependent methyltransferase -
QPL81_RS14110 (QPL81_14110) 2317050..2318726 - 1677 WP_284557501.1 alpha-keto acid decarboxylase family protein -
QPL81_RS14115 (QPL81_14115) 2318853..2319335 + 483 WP_000191892.1 MarR family winged helix-turn-helix transcriptional regulator -
QPL81_RS14120 (QPL81_14120) 2319503..2320240 + 738 WP_000594132.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QPL81_RS14125 (QPL81_14125) 2320427..2321167 + 741 WP_000155917.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QPL81_RS14130 (QPL81_14130) 2321280..2321405 + 126 WP_000588713.1 hypothetical protein Antitoxin
QPL81_RS14135 (QPL81_14135) 2321481..2321657 + 177 WP_000808012.1 stage II sporulation protein SB -
QPL81_RS14140 (QPL81_14140) 2321706..2322095 - 390 WP_000732294.1 YxeA family protein -
QPL81_RS14145 (QPL81_14145) 2322339..2323808 + 1470 WP_284557502.1 beta-Ala-His dipeptidase -
QPL81_RS14150 (QPL81_14150) 2324119..2324928 + 810 WP_000678381.1 papain-like cysteine protease family protein -
QPL81_RS14155 (QPL81_14155) 2324956..2325558 + 603 WP_097895978.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28446.03 Da        Isoelectric Point: 7.3946

>T282925 WP_000155917.1 NZ_CP126520:2320427-2321167 [Bacillus toyonensis]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4951.43 Da        Isoelectric Point: 4.1079

>AT282925 WP_000588713.1 NZ_CP126520:2321280-2321405 [Bacillus toyonensis]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0FNW8

Antitoxin

Source ID Structure
AlphaFold DB J8KE32

References