Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2367835..2368810 Replicon chromosome
Accession NZ_CP126515
Organism Bacillus anthracis strain Mn106-1 head2 chi

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag QPL80_RS12975 Protein ID WP_284566365.1
Coordinates 2367835..2368572 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J9W3Q2
Locus tag QPL80_RS12980 Protein ID WP_000594606.1
Coordinates 2368685..2368810 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL80_RS12945 (QPL80_12980) 2362910..2363620 + 711 WP_071729146.1 class I SAM-dependent methyltransferase -
QPL80_RS12950 (QPL80_12985) 2363740..2364147 + 408 WP_088312951.1 VOC family protein -
QPL80_RS12955 (QPL80_12990) 2364253..2364345 + 93 Protein_2360 methyltransferase -
QPL80_RS12960 (QPL80_12995) 2364467..2366152 - 1686 WP_284566284.1 alpha-keto acid decarboxylase family protein -
QPL80_RS12965 (QPL80_13000) 2366259..2366741 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
QPL80_RS12970 (QPL80_13005) 2366909..2367646 + 738 WP_088312955.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QPL80_RS12975 (QPL80_13010) 2367835..2368572 + 738 WP_284566365.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QPL80_RS12980 (QPL80_13015) 2368685..2368810 + 126 WP_000594606.1 hypothetical protein Antitoxin
QPL80_RS12985 (QPL80_13020) 2368886..2369062 + 177 WP_000852613.1 stage II sporulation protein SB -
QPL80_RS12990 (QPL80_13025) 2369106..2369381 - 276 WP_001041552.1 hypothetical protein -
QPL80_RS12995 (QPL80_13030) 2369661..2369898 - 238 Protein_2368 hypothetical protein -
QPL80_RS13000 (QPL80_13035) 2370035..2370160 + 126 WP_284566285.1 hypothetical protein -
QPL80_RS13005 (QPL80_13040) 2370236..2370412 + 177 WP_284566286.1 stage II sporulation protein SB -
QPL80_RS13010 (QPL80_13045) 2370556..2372025 + 1470 WP_284566287.1 beta-Ala-His dipeptidase -
QPL80_RS13015 (QPL80_13050) 2372606..2373076 - 471 WP_000771836.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28357.07 Da        Isoelectric Point: 8.2269

>T282923 WP_284566365.1 NZ_CP126515:2367835-2368572 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWYTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4860.23 Da        Isoelectric Point: 3.9507

>AT282923 WP_000594606.1 NZ_CP126515:2368685-2368810 [Bacillus anthracis]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEDLEDELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9W3Q2

References