Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 260007..260649 Replicon chromosome
Accession NZ_CP126515
Organism Bacillus anthracis strain Mn106-1 head2 chi

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QPL80_RS02005 Protein ID WP_000635963.1
Coordinates 260299..260649 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QPL80_RS02000 Protein ID WP_000004570.1
Coordinates 260007..260294 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPL80_RS01975 (QPL80_01975) 255323..256285 + 963 WP_000961148.1 UV DNA damage repair endonuclease UvsE -
QPL80_RS01980 (QPL80_01980) 256278..256850 - 573 WP_071728601.1 rhomboid family intramembrane serine protease -
QPL80_RS01985 (QPL80_01985) 256943..257302 + 360 WP_000635047.1 holo-ACP synthase -
QPL80_RS01990 (QPL80_01990) 257459..258409 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
QPL80_RS01995 (QPL80_01995) 258528..259697 + 1170 WP_000390607.1 alanine racemase -
QPL80_RS02000 (QPL80_02000) 260007..260294 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QPL80_RS02005 (QPL80_02005) 260299..260649 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QPL80_RS02010 (QPL80_02010) 260717..262885 + 2169 WP_071728600.1 Tex family protein -
QPL80_RS02015 (QPL80_02015) 262943..263059 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QPL80_RS02020 (QPL80_02020) 263255..263713 + 459 WP_071728599.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282922 WP_000635963.1 NZ_CP126515:260299-260649 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282922 WP_000004570.1 NZ_CP126515:260007-260294 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References