Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1261693..1262329 Replicon chromosome
Accession NZ_CP126496
Organism Bacillus paralicheniformis strain DY4

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QN340_RS06195 Protein ID WP_003179128.1
Coordinates 1261979..1262329 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QN340_RS06190 Protein ID WP_006638778.1
Coordinates 1261693..1261974 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN340_RS06170 (QN340_06170) 1256803..1258287 + 1485 WP_041817155.1 PH domain-containing protein -
QN340_RS06175 (QN340_06175) 1258284..1258883 - 600 WP_020450255.1 rhomboid family intramembrane serine protease -
QN340_RS06180 (QN340_06180) 1259227..1260186 + 960 WP_165395380.1 outer membrane lipoprotein carrier protein LolA -
QN340_RS06185 (QN340_06185) 1260412..1261581 + 1170 WP_041817156.1 alanine racemase -
QN340_RS06190 (QN340_06190) 1261693..1261974 + 282 WP_006638778.1 hypothetical protein Antitoxin
QN340_RS06195 (QN340_06195) 1261979..1262329 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QN340_RS06200 (QN340_06200) 1262447..1263274 + 828 WP_020450258.1 RsbT co-antagonist protein RsbRA -
QN340_RS06205 (QN340_06205) 1263278..1263643 + 366 WP_020450259.1 STAS domain-containing protein -
QN340_RS06210 (QN340_06210) 1263646..1264047 + 402 WP_020450260.1 anti-sigma regulatory factor -
QN340_RS06215 (QN340_06215) 1264058..1265065 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
QN340_RS06220 (QN340_06220) 1265124..1265450 + 327 WP_020450262.1 anti-sigma factor antagonist -
QN340_RS06225 (QN340_06225) 1265450..1265932 + 483 WP_020450263.1 anti-sigma B factor RsbW -
QN340_RS06230 (QN340_06230) 1265898..1266689 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
QN340_RS06235 (QN340_06235) 1266686..1267285 + 600 WP_020450265.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T282920 WP_003179128.1 NZ_CP126496:1261979-1262329 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT282920 WP_006638778.1 NZ_CP126496:1261693-1261974 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References