Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2328237..2329215 Replicon chromosome
Accession NZ_CP126474
Organism Bacillus thuringiensis strain DHC4

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag QOM09_RS12125 Protein ID WP_000624977.1
Coordinates 2328237..2328974 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag QOM09_RS12130 Protein ID WP_000237818.1
Coordinates 2329087..2329215 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOM09_RS12105 (QOM09_12105) 2323880..2324662 + 783 WP_000381800.1 class I SAM-dependent methyltransferase -
QOM09_RS12110 (QOM09_12110) 2324820..2326505 - 1686 WP_058839616.1 alpha-keto acid decarboxylase family protein -
QOM09_RS12115 (QOM09_12115) 2326613..2327095 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
QOM09_RS12120 (QOM09_12120) 2327262..2327999 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QOM09_RS12125 (QOM09_12125) 2328237..2328974 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QOM09_RS12130 (QOM09_12130) 2329087..2329215 + 129 WP_000237818.1 hypothetical protein Antitoxin
QOM09_RS12135 (QOM09_12135) 2329288..2329464 + 177 WP_000852629.1 stage II sporulation protein SB -
QOM09_RS12140 (QOM09_12140) 2329483..2329872 - 390 WP_000713866.1 YxeA family protein -
QOM09_RS12145 (QOM09_12145) 2330084..2331556 + 1473 WP_053513522.1 beta-Ala-His dipeptidase -
QOM09_RS12150 (QOM09_12150) 2331799..2332608 + 810 WP_000678509.1 papain-like cysteine protease family protein -
QOM09_RS12155 (QOM09_12155) 2332634..2333236 + 603 WP_053513524.1 hypothetical protein -
QOM09_RS12160 (QOM09_12160) 2333477..2333728 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T282919 WP_000624977.1 NZ_CP126474:2328237-2328974 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT282919 WP_000237818.1 NZ_CP126474:2329087-2329215 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References