Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 232580..233222 Replicon chromosome
Accession NZ_CP126474
Organism Bacillus thuringiensis strain DHC4

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QOM09_RS01330 Protein ID WP_000635965.1
Coordinates 232872..233222 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QOM09_RS01325 Protein ID WP_000004570.1
Coordinates 232580..232867 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOM09_RS01300 (QOM09_01300) 227897..228859 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
QOM09_RS01305 (QOM09_01305) 228852..229424 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
QOM09_RS01310 (QOM09_01310) 229518..229877 + 360 WP_000583417.1 holo-ACP synthase -
QOM09_RS01315 (QOM09_01315) 230034..230984 + 951 WP_053514347.1 outer membrane lipoprotein carrier protein LolA -
QOM09_RS01320 (QOM09_01320) 231102..232271 + 1170 WP_053514326.1 alanine racemase -
QOM09_RS01325 (QOM09_01325) 232580..232867 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QOM09_RS01330 (QOM09_01330) 232872..233222 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QOM09_RS01335 (QOM09_01335) 233290..235458 + 2169 WP_000426236.1 Tex family protein -
QOM09_RS01340 (QOM09_01340) 235516..235632 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QOM09_RS01345 (QOM09_01345) 235828..236286 + 459 WP_000344241.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T282918 WP_000635965.1 NZ_CP126474:232872-233222 [Bacillus thuringiensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282918 WP_000004570.1 NZ_CP126474:232580-232867 [Bacillus thuringiensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References