Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241200..241842 Replicon chromosome
Accession NZ_CP126463
Organism Bacillus anthracis strain BHY1401

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QN296_RS01325 Protein ID WP_000635963.1
Coordinates 241492..241842 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QN296_RS01320 Protein ID WP_000004570.1
Coordinates 241200..241487 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN296_RS01295 (QN296_01295) 236516..237478 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
QN296_RS01300 (QN296_01300) 237471..238043 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
QN296_RS01305 (QN296_01305) 238136..238495 + 360 WP_000635040.1 holo-ACP synthase -
QN296_RS01310 (QN296_01310) 238652..239602 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
QN296_RS01315 (QN296_01315) 239721..240890 + 1170 WP_000390596.1 alanine racemase -
QN296_RS01320 (QN296_01320) 241200..241487 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QN296_RS01325 (QN296_01325) 241492..241842 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QN296_RS01330 (QN296_01330) 241910..244078 + 2169 WP_000426225.1 Tex family protein -
QN296_RS01335 (QN296_01335) 244136..244252 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QN296_RS01340 (QN296_01340) 244448..244906 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282916 WP_000635963.1 NZ_CP126463:241492-241842 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282916 WP_000004570.1 NZ_CP126463:241200-241487 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References