Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 274452..275082 Replicon chromosome
Accession NZ_CP126462
Organism Caminicella sporogenes strain HV-G

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QNI18_RS01400 Protein ID WP_284552984.1
Coordinates 274452..274802 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QNI18_RS01405 Protein ID WP_284552985.1
Coordinates 274804..275082 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNI18_RS01380 (QNI18_01380) 270413..271522 - 1110 WP_284552981.1 glycosyltransferase -
QNI18_RS01385 (QNI18_01385) 271550..272074 - 525 WP_072967129.1 DapH/DapD/GlmU-related protein -
QNI18_RS01390 (QNI18_01390) 272078..273646 - 1569 WP_284552982.1 murein biosynthesis integral membrane protein MurJ -
QNI18_RS01395 (QNI18_01395) 273716..274282 - 567 WP_284552983.1 hypothetical protein -
QNI18_RS01400 (QNI18_01400) 274452..274802 - 351 WP_284552984.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNI18_RS01405 (QNI18_01405) 274804..275082 - 279 WP_284552985.1 ribbon-helix-helix protein, CopG family Antitoxin
QNI18_RS01410 (QNI18_01410) 275220..276389 - 1170 WP_284552986.1 alanine racemase -
QNI18_RS01415 (QNI18_01415) 276408..277037 - 630 WP_284552987.1 outer-membrane lipoprotein carrier protein LolA -
QNI18_RS01420 (QNI18_01420) 277119..278666 - 1548 WP_284552988.1 NAD(P)H-hydrate dehydratase -
QNI18_RS01425 (QNI18_01425) 278758..279123 - 366 WP_284552989.1 holo-ACP synthase -
QNI18_RS01430 (QNI18_01430) 279276..279872 - 597 WP_284552990.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12866.21 Da        Isoelectric Point: 9.6003

>T282915 WP_284552984.1 NZ_CP126462:c274802-274452 [Caminicella sporogenes]
MLIKRGDVFYADLSPVIGSEQGGVRPVLVIQNDIGNKYSPTVIIAAITSQINKAKLPTHVELNGLKNGLPKDSVILLEQV
RTIDKRRFIEKICRLDENIMKKVNEALMISLGLVDI

Download         Length: 351 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10891.75 Da        Isoelectric Point: 4.7502

>AT282915 WP_284552985.1 NZ_CP126462:c275082-274804 [Caminicella sporogenes]
MAESRRIMVCVPDSLLQEVDYIVKLENKNRSEFIREAMKLYLRERKKMDIREAMKIGYQEMASINLVYAEMGMDVDMDCL
KRYEAQLAAECE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References