Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2226552..2227188 Replicon chromosome
Accession NZ_CP126456
Organism Bacillus altitudinis strain KRS010

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QLQ03_RS11350 Protein ID WP_003214169.1
Coordinates 2226838..2227188 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QLQ03_RS11345 Protein ID WP_003214273.1
Coordinates 2226552..2226833 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ03_RS11325 2222706..2223311 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
QLQ03_RS11330 2223406..2223771 + 366 WP_058214404.1 holo-ACP synthase -
QLQ03_RS11335 2223932..2224948 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
QLQ03_RS11340 2225077..2226258 + 1182 WP_284564914.1 alanine racemase -
QLQ03_RS11345 2226552..2226833 + 282 WP_003214273.1 hypothetical protein Antitoxin
QLQ03_RS11350 2226838..2227188 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QLQ03_RS11355 2227305..2228135 + 831 WP_008346908.1 RsbT co-antagonist protein RsbRA -
QLQ03_RS11360 2228140..2228508 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QLQ03_RS11365 2228511..2228912 + 402 WP_019744214.1 anti-sigma regulatory factor -
QLQ03_RS11370 2228923..2229930 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
QLQ03_RS11375 2229990..2230319 + 330 WP_008346902.1 anti-sigma factor antagonist -
QLQ03_RS11380 2230316..2230804 + 489 WP_019744216.1 anti-sigma B factor RsbW -
QLQ03_RS11385 2230770..2231558 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
QLQ03_RS11390 2231558..2232157 + 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T282914 WP_003214169.1 NZ_CP126456:2226838-2227188 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT282914 WP_003214273.1 NZ_CP126456:2226552-2226833 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References