Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 259074..259710 Replicon chromosome
Accession NZ_CP126446
Organism Pontibacillus chungwhensis strain HN14

Toxin (Protein)


Gene name pemK Uniprot ID A0A0A2UP65
Locus tag QNI29_RS01465 Protein ID WP_036786621.1
Coordinates 259360..259710 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNI29_RS01460 Protein ID WP_284526990.1
Coordinates 259074..259355 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNI29_RS01440 (QNI29_01440) 254570..254926 + 357 WP_231419644.1 holo-ACP synthase -
QNI29_RS01445 (QNI29_01445) 255001..256515 + 1515 WP_231419645.1 NAD(P)H-hydrate dehydratase -
QNI29_RS01450 (QNI29_01450) 256570..257595 + 1026 WP_231419646.1 outer membrane lipoprotein carrier protein LolA -
QNI29_RS01455 (QNI29_01455) 257745..258917 + 1173 WP_231419647.1 alanine racemase -
QNI29_RS01460 (QNI29_01460) 259074..259355 + 282 WP_284526990.1 antitoxin Antitoxin
QNI29_RS01465 (QNI29_01465) 259360..259710 + 351 WP_036786621.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNI29_RS01470 (QNI29_01470) 259943..260812 + 870 WP_231419649.1 RsbT co-antagonist protein RsbRA -
QNI29_RS01475 (QNI29_01475) 260818..261174 + 357 WP_255688851.1 STAS domain-containing protein -
QNI29_RS01480 (QNI29_01480) 261179..261580 + 402 WP_036786615.1 anti-sigma regulatory factor -
QNI29_RS01485 (QNI29_01485) 261595..262605 + 1011 WP_231419650.1 PP2C family protein-serine/threonine phosphatase -
QNI29_RS01490 (QNI29_01490) 262671..263006 + 336 WP_231419651.1 STAS domain-containing protein -
QNI29_RS01495 (QNI29_01495) 263006..263485 + 480 WP_231419652.1 anti-sigma B factor RsbW -
QNI29_RS01500 (QNI29_01500) 263457..264248 + 792 WP_231419653.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12962.97 Da        Isoelectric Point: 4.8668

>T282912 WP_036786621.1 NZ_CP126446:259360-259710 [Pontibacillus chungwhensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAERYGFERDSVILLEQI
RTIDKQRLTDKITHLDEAMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10761.25 Da        Isoelectric Point: 4.9002

>AT282912 WP_284526990.1 NZ_CP126446:259074-259355 [Pontibacillus chungwhensis]
ILVSDSSQEIVVKLPQHLLNELDGMVQLENGDRSDFIYQATKMYLRERKKRHIRESMRQGYMEMAKINLNIASEAFQAEE
EAETTCERLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2UP65

Antitoxin

Source ID Structure

References