Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 22515..23037 Replicon plasmid pNN5A
Accession NZ_CP126349
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag QN227_RS22170 Protein ID WP_000220561.1
Coordinates 22756..23037 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QN227_RS22165 Protein ID WP_000121743.1
Coordinates 22515..22766 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS22145 (18638) 18638..18991 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
QN227_RS22150 (19128) 19128..19574 - 447 WP_001074384.1 hypothetical protein -
QN227_RS22155 (19578) 19578..20420 - 843 WP_000435064.1 replication initiation protein -
QN227_RS22160 (20441) 20441..21280 - 840 WP_024129959.1 replication initiation protein -
QN227_RS22165 (22515) 22515..22766 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QN227_RS22170 (22756) 22756..23037 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN227_RS22175 (23276) 23276..23368 - 93 Protein_26 IS6 family transposase -
QN227_RS22180 (23534) 23534..24733 - 1200 WP_000948429.1 IS91 family transposase -
QN227_RS22185 (24743) 24743..24931 - 189 WP_000957857.1 hypothetical protein -
QN227_RS22190 (25051) 25051..26481 + 1431 Protein_29 IS4-like element IS50R family transposase -
QN227_RS22195 (26510) 26510..27304 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
QN227_RS22200 (27325) 27325..27561 + 237 Protein_31 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-IIa / blaCTX-M-55 / blaTEM-1B / dfrA14 - 1..49842 49842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T282911 WP_000220561.1 NZ_CP126349:22756-23037 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT282911 WP_000121743.1 NZ_CP126349:22515-22766 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References