Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4134256..4134753 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QN227_RS19810 Protein ID WP_001173343.1
Coordinates 4134256..4134429 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QN227_RS19815 Protein ID WP_000398619.1
Coordinates 4134457..4134753 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS19800 (4130926) 4130926..4132383 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QN227_RS19805 (4132620) 4132620..4134137 + 1518 WP_001295074.1 lysine--tRNA ligase -
QN227_RS19810 (4134256) 4134256..4134429 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QN227_RS19815 (4134457) 4134457..4134753 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QN227_RS19820 (4134980) 4134980..4135252 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QN227_RS19825 (4135264) 4135264..4135494 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QN227_RS19830 (4135675) 4135675..4137306 + 1632 WP_033557601.1 sensor histidine kinase -
QN227_RS19835 (4137303) 4137303..4138022 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T282909 WP_001173343.1 NZ_CP126348:c4134429-4134256 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT282909 WP_000398619.1 NZ_CP126348:c4134753-4134457 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References