Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4037898..4038493 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QN227_RS19310 Protein ID WP_000239579.1
Coordinates 4037898..4038248 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QN227_RS19315 Protein ID WP_001223208.1
Coordinates 4038242..4038493 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS19290 (4033344) 4033344..4034366 - 1023 WP_001367906.1 ABC transporter permease -
QN227_RS19295 (4034380) 4034380..4035882 - 1503 WP_033557615.1 sugar ABC transporter ATP-binding protein -
QN227_RS19300 (4036022) 4036022..4036978 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QN227_RS19305 (4037288) 4037288..4037818 + 531 WP_033557614.1 inorganic diphosphatase -
QN227_RS19310 (4037898) 4037898..4038248 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QN227_RS19315 (4038242) 4038242..4038493 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QN227_RS19320 (4038705) 4038705..4039046 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QN227_RS19325 (4039049) 4039049..4042828 - 3780 WP_033557613.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T282908 WP_000239579.1 NZ_CP126348:c4038248-4037898 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT282908 WP_001223208.1 NZ_CP126348:c4038493-4038242 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References