282905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3390766..3391603 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QN227_RS16275 Protein ID WP_000227784.1
Coordinates 3391061..3391603 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QN227_RS16270 Protein ID WP_001297137.1
Coordinates 3390766..3391077 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS16245 (3385786) 3385786..3386733 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QN227_RS16250 (3386755) 3386755..3388746 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QN227_RS16255 (3388736) 3388736..3389350 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QN227_RS16260 (3389350) 3389350..3389679 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QN227_RS16265 (3389691) 3389691..3390581 + 891 WP_000971336.1 heme o synthase -
QN227_RS16270 (3390766) 3390766..3391077 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QN227_RS16275 (3391061) 3391061..3391603 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QN227_RS16280 (3391659) 3391659..3392594 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QN227_RS16285 (3393002) 3393002..3394366 + 1365 WP_001000975.1 MFS transporter -
QN227_RS16290 (3394494) 3394494..3394985 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QN227_RS16295 (3395153) 3395153..3396064 + 912 WP_284556540.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T282905 WP_000227784.1 NZ_CP126348:3391061-3391603 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT282905 WP_001297137.1 NZ_CP126348:3390766-3391077 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References