Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3356690..3357308 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QN227_RS16105 Protein ID WP_001291435.1
Coordinates 3357090..3357308 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QN227_RS16100 Protein ID WP_000344800.1
Coordinates 3356690..3357064 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS16090 (3351779) 3351779..3352972 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN227_RS16095 (3352995) 3352995..3356144 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QN227_RS16100 (3356690) 3356690..3357064 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QN227_RS16105 (3357090) 3357090..3357308 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QN227_RS16110 (3357479) 3357479..3358030 + 552 WP_000102564.1 maltose O-acetyltransferase -
QN227_RS16115 (3358146) 3358146..3358616 + 471 WP_000136192.1 YlaC family protein -
QN227_RS16120 (3358780) 3358780..3360330 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QN227_RS16125 (3360372) 3360372..3360725 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QN227_RS16135 (3361104) 3361104..3361415 + 312 WP_000409911.1 MGMT family protein -
QN227_RS16140 (3361446) 3361446..3362018 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282904 WP_001291435.1 NZ_CP126348:3357090-3357308 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT282904 WP_000344800.1 NZ_CP126348:3356690-3357064 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References