Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1320323..1320948 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QN227_RS06390 Protein ID WP_000911330.1
Coordinates 1320550..1320948 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QN227_RS06385 Protein ID WP_000450524.1
Coordinates 1320323..1320550 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS06360 (1316126) 1316126..1316596 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QN227_RS06365 (1316596) 1316596..1317168 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QN227_RS06370 (1317314) 1317314..1318192 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QN227_RS06375 (1318209) 1318209..1319243 + 1035 WP_033557475.1 outer membrane protein assembly factor BamC -
QN227_RS06380 (1319456) 1319456..1320169 + 714 WP_033557474.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QN227_RS06385 (1320323) 1320323..1320550 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QN227_RS06390 (1320550) 1320550..1320948 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QN227_RS06395 (1321095) 1321095..1321958 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QN227_RS06400 (1321973) 1321973..1323988 + 2016 WP_033557473.1 tRNA cytosine(34) acetyltransferase TmcA -
QN227_RS06405 (1324062) 1324062..1324760 + 699 WP_000679812.1 esterase -
QN227_RS06410 (1324870) 1324870..1325070 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T282897 WP_000911330.1 NZ_CP126348:1320550-1320948 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT282897 WP_000450524.1 NZ_CP126348:1320323-1320550 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References