Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 863691..864345 Replicon chromosome
Accession NZ_CP126348
Organism Escherichia coli strain NN5

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QN227_RS04225 Protein ID WP_000244777.1
Coordinates 863938..864345 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QN227_RS04220 Protein ID WP_000354046.1
Coordinates 863691..863957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN227_RS04195 (858860) 858860..859603 + 744 WP_033557373.1 SDR family oxidoreductase -
QN227_RS04200 (859660) 859660..861093 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QN227_RS04205 (861138) 861138..861449 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QN227_RS04210 (861613) 861613..862272 + 660 WP_033557372.1 hemolysin III family protein -
QN227_RS04215 (862468) 862468..863448 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QN227_RS04220 (863691) 863691..863957 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QN227_RS04225 (863938) 863938..864345 + 408 WP_000244777.1 protein YgfX Toxin
QN227_RS04230 (864385) 864385..864906 - 522 WP_001055874.1 flavodoxin FldB -
QN227_RS04235 (865018) 865018..865914 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QN227_RS04240 (865939) 865939..866649 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QN227_RS04245 (866655) 866655..868388 + 1734 WP_033557371.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T282894 WP_000244777.1 NZ_CP126348:863938-864345 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT282894 WP_000354046.1 NZ_CP126348:863691-863957 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References