Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4208743..4209338 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QN223_RS20730 Protein ID WP_000239579.1
Coordinates 4208743..4209093 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QN223_RS20735 Protein ID WP_001223208.1
Coordinates 4209087..4209338 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS20710 (4204019) 4204019..4205041 - 1023 WP_001339490.1 ABC transporter permease -
QN223_RS20715 (4205055) 4205055..4206557 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
QN223_RS20720 (4206867) 4206867..4207823 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QN223_RS20725 (4208133) 4208133..4208663 + 531 WP_000055072.1 inorganic diphosphatase -
QN223_RS20730 (4208743) 4208743..4209093 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QN223_RS20735 (4209087) 4209087..4209338 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QN223_RS20740 (4209551) 4209551..4209892 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QN223_RS20745 (4209895) 4209895..4213674 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T282887 WP_000239579.1 NZ_CP126345:c4209093-4208743 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT282887 WP_001223208.1 NZ_CP126345:c4209338-4209087 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References