Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3503583..3504201 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QN223_RS17200 Protein ID WP_001291435.1
Coordinates 3503983..3504201 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QN223_RS17195 Protein ID WP_000344800.1
Coordinates 3503583..3503957 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS17185 (3498672) 3498672..3499865 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN223_RS17190 (3499888) 3499888..3503037 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QN223_RS17195 (3503583) 3503583..3503957 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QN223_RS17200 (3503983) 3503983..3504201 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QN223_RS17205 (3504373) 3504373..3504924 + 552 WP_000102568.1 maltose O-acetyltransferase -
QN223_RS17210 (3505040) 3505040..3505510 + 471 WP_000136192.1 YlaC family protein -
QN223_RS17215 (3505674) 3505674..3507224 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QN223_RS17220 (3507266) 3507266..3507619 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QN223_RS17230 (3507998) 3507998..3508309 + 312 WP_000409911.1 MGMT family protein -
QN223_RS17235 (3508340) 3508340..3508912 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282884 WP_001291435.1 NZ_CP126345:3503983-3504201 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT282884 WP_000344800.1 NZ_CP126345:3503583-3503957 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References