Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2460440..2461078 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QN223_RS12035 Protein ID WP_000813794.1
Coordinates 2460902..2461078 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QN223_RS12030 Protein ID WP_001270286.1
Coordinates 2460440..2460856 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS12010 (2455592) 2455592..2456533 - 942 WP_001251319.1 ABC transporter permease -
QN223_RS12015 (2456534) 2456534..2457547 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QN223_RS12020 (2457565) 2457565..2458710 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QN223_RS12025 (2458955) 2458955..2460361 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QN223_RS12030 (2460440) 2460440..2460856 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QN223_RS12035 (2460902) 2460902..2461078 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QN223_RS12040 (2461300) 2461300..2461530 + 231 WP_000494244.1 YncJ family protein -
QN223_RS12045 (2461622) 2461622..2463583 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QN223_RS12050 (2463656) 2463656..2464192 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QN223_RS12055 (2464284) 2464284..2465459 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2465499..2466764 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T282882 WP_000813794.1 NZ_CP126345:c2461078-2460902 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT282882 WP_001270286.1 NZ_CP126345:c2460856-2460440 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References