Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2371835..2373423 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name hipA Uniprot ID U9XU38
Locus tag QN223_RS11640 Protein ID WP_001125455.1
Coordinates 2372101..2373423 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QN223_RS11635 Protein ID WP_001296726.1
Coordinates 2371835..2372101 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS11635 (2371835) 2371835..2372101 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QN223_RS11640 (2372101) 2372101..2373423 + 1323 WP_001125455.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QN223_RS11645 (2373735) 2373735..2373943 + 209 Protein_2280 AraC family transcriptional regulator -
QN223_RS11650 (2374377) 2374377..2374940 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QN223_RS11655 (2375301) 2375301..2376011 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2371835..2387924 16089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49321.93 Da        Isoelectric Point: 8.8753

>T282881 WP_001125455.1 NZ_CP126345:2372101-2373423 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT282881 WP_001296726.1 NZ_CP126345:2371835-2372101 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XU38

Antitoxin

Source ID Structure

References