Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1404032..1404657 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QN223_RS06980 Protein ID WP_000911330.1
Coordinates 1404259..1404657 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QN223_RS06975 Protein ID WP_000450524.1
Coordinates 1404032..1404259 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS06950 (1399835) 1399835..1400305 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QN223_RS06955 (1400305) 1400305..1400877 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QN223_RS06960 (1401023) 1401023..1401901 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QN223_RS06965 (1401918) 1401918..1402952 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QN223_RS06970 (1403165) 1403165..1403878 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QN223_RS06975 (1404032) 1404032..1404259 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QN223_RS06980 (1404259) 1404259..1404657 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QN223_RS06985 (1404804) 1404804..1405667 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QN223_RS06990 (1405682) 1405682..1407697 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QN223_RS06995 (1407771) 1407771..1408469 + 699 WP_000679823.1 esterase -
QN223_RS07000 (1408579) 1408579..1408779 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T282874 WP_000911330.1 NZ_CP126345:1404259-1404657 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT282874 WP_000450524.1 NZ_CP126345:1404032-1404259 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References