Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 701673..702508 Replicon chromosome
Accession NZ_CP126345
Organism Escherichia coli strain DX6

Toxin (Protein)


Gene name yeeV Uniprot ID A0A763DSF8
Locus tag QN223_RS03390 Protein ID WP_047928871.1
Coordinates 702131..702508 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QN223_RS03385 Protein ID WP_047928872.1
Coordinates 701673..702041 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN223_RS03360 (698555) 698555..699373 + 819 WP_182913012.1 DUF932 domain-containing protein -
QN223_RS03365 (699711) 699711..700184 + 474 WP_001355870.1 antirestriction protein -
QN223_RS03370 (700200) 700200..700676 + 477 WP_001186771.1 RadC family protein -
QN223_RS03375 (700739) 700739..700960 + 222 WP_000692327.1 DUF987 domain-containing protein -
QN223_RS03380 (700979) 700979..701623 + 645 WP_047928873.1 hypothetical protein -
QN223_RS03385 (701673) 701673..702041 + 369 WP_047928872.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QN223_RS03390 (702131) 702131..702508 + 378 WP_047928871.1 TA system toxin CbtA family protein Toxin
QN223_RS03395 (702505) 702505..702654 + 150 Protein_665 DUF5983 family protein -
QN223_RS03400 (702730) 702730..702927 + 198 WP_096093965.1 DUF957 domain-containing protein -
QN223_RS03405 (703012) 703012..703857 + 846 WP_072650597.1 DUF4942 domain-containing protein -
QN223_RS03415 (704157) 704157..704663 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
QN223_RS03420 (704742) 704742..706583 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13941.88 Da        Isoelectric Point: 7.3222

>T282871 WP_047928871.1 NZ_CP126345:702131-702508 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNGITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13757.47 Da        Isoelectric Point: 5.0907

>AT282871 WP_047928872.1 NZ_CP126345:701673-702041 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEDNQLHYLADRAGIRGRFSDADAYHLDQALPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A763DSF8

Antitoxin

Source ID Structure

References