Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 53445..53967 Replicon plasmid pDAX4A
Accession NZ_CP126344
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag QN220_RS23040 Protein ID WP_000220560.1
Coordinates 53445..53726 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QN220_RS23045 Protein ID WP_000121743.1
Coordinates 53716..53967 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS23020 (49855) 49855..51291 - 1437 WP_000105383.1 glutathione synthase -
QN220_RS23025 (51558) 51558..52262 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
QN220_RS23030 (52355) 52355..52663 - 309 Protein_72 replication initiation protein -
QN220_RS23040 (53445) 53445..53726 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN220_RS23045 (53716) 53716..53967 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QN220_RS23050 (55124) 55124..55960 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
QN220_RS23055 (56000) 56000..56446 + 447 Protein_77 hypothetical protein -
QN220_RS23060 (56583) 56583..56939 + 357 WP_000456533.1 DNA distortion polypeptide 3 -
QN220_RS23065 (56936) 56936..57913 - 978 WP_024245156.1 hypothetical protein -
QN220_RS23070 (57938) 57938..58219 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1A / tet(M) / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / qnrS2 pet 1..130224 130224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T282867 WP_000220560.1 NZ_CP126344:c53726-53445 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT282867 WP_000121743.1 NZ_CP126344:c53967-53716 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References